Early-pregnancy glucose-lipid signatures and metabolic heterogeneity of gestational diabetes with extension to hypertensive comorbidity in singleton and twin pregnancies: a multicenter cohort study.

Lin, Minhuan; Meng, Zhaoran; Chen, Yiqing; Xia, Shuting; Ye, Yingnan; Ye, Ting; Cai, Jian; Huang, Linhuan; Wen, Li; Luo, Yanmin

doi:10.1186/s12944-026-03009-x

Early-pregnancy glucose-lipid signatures and metabolic heterogeneity of gestational diabetes with extension to hypertensive comorbidity in singleton and twin pregnancies: a multicenter cohort study.

2026-07-16, Lipids in Health and Disease (10.1186/s12944-026-03009-x) (online)
Minhuan Lin, Zhaoran Meng, Yiqing Chen, Shuting Xia, Yingnan Ye, Ting Ye, Jian Cai, Linhuan Huang, Li Wen, and Yanmin Luo (?)

Early pregnancy is a critical window for metabolic adaptation, marked by coordinated regulation of glucose and lipid metabolism. Disruption of this balance may contribute to gestational diabetes mellitus (GDM), a condition increasingly recognized as metabolically heterogeneous. Whether early-pregnancy glucose-lipid indices capture this heterogeneity and extend to hypertensive disorders of pregnancy (HDP) remains unclear.

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Early-pregnancy glucose-lipid signatures and metabolic heterogeneity of gestational diabetes with extension to hypertensive comorbidity in singleton and twin pregnancies: a multicenter cohort study.