Pathogenic signatures and therapeutic evaluation of emergent MPXV Clade Ib in low-susceptibility and immunocompromised mouse models.

Han, Hongyu; Wang, Xiaowei; Wu, Yongchang; Yang, Xiaorong; Qian, Peng; Xie, Xiaoqing; Jiang, Dongmei; Wu, Shan; Tang, Xiaoping; Pang, Quanhai; Yu, Haisheng

doi:10.1186/s12866-026-05273-4

Pathogenic signatures and therapeutic evaluation of emergent MPXV Clade Ib in low-susceptibility and immunocompromised mouse models.

2026-06-09, BMC Microbiology (10.1186/s12866-026-05273-4) (online)
Hongyu Han, Xiaowei Wang, Yongchang Wu, Xiaorong Yang, Peng Qian, Xiaoqing Xie, Dongmei Jiang, Shan Wu, Xiaoping Tang, Quanhai Pang, and Haisheng Yu (?)

Monkeypox (Mpox) is a zoonotic disease that threatens global public health. Different clades of monkeypox virus (MPXV) vary in transmissibility and pathogenicity. In 2023, a Clade Ib MPXV variant emerged in the Democratic Republic of the Congo, continued to spread in parts of Africa, and subsequently spilled over to other regions, posing new challenges for outbreak prevention and control.

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Pathogenic signatures and therapeutic evaluation of emergent MPXV Clade Ib in low-susceptibility and immunocompromised mouse models.